Endocrine disruptors

Rovaltain Research Company

Biocide and Plant Protection Products Regulations  

From the 20th of October 2018, the active substance, herbicide safener or synergist is considered as endocrine disruptors if they present properties that could disrupt the endocrine system. Indeed it can cause adverse effects to human or to non-target organisms if it answers to the criteria listed here below (except if it is proven that the adverse effects does not affect humans and are not relevant at the level of the sub-population for the non-target organisms):

 – The active substance present an adverse effect in an intact organism or its progeny or sub-population namely a change in the morphology, physiology, growth, development, reproduction or life span of an organism, system, or (sub) population that results in an impairment of functional capacity, an impairment of the capacity to compensate for additional stress, or an increase in susceptibility to other influences.; 

– The active substance has an endocrine mode of action, i.e. which alters function(s) of the endocrine system and consequently causes adverse health effects in an intact organism.

– An undesirable effect is a consequence of the endocrine mode of action.

Tests to determinate the ED properties of your substances

RRCo offers to follow the recommendations of the Guide to identify the Endocrine Disruptors within the framework of the regulations No 528/2012 and 1107/2009 of the 7th of June 2018.

The tests listed here below are available in our facilities:

  • OECD 231 : Amphibian Metamorphosis Assay
  • OECD 229 : Fish Short Term Reproduction Assay
  • OECD 230 : 21-day Fish Assay
  • OECD 148 : Androgenised Female stickleback screen
  • OECD 234 : Fish Sexual Development Test
  • OECD 241 : The Larval Amphibian Growth and Development Assay (LAGDA)
  • OECD 210 : Fish, Early-life Stage Toxicity Test
  • OECD 201 : New guidance document on harpacticoid copepod development and reproduction test with Amphiascus
  • OECD 242 : Potamopyrgus antipodarum Reproduction Test
  • OECD 243 : Lymnaea stagnalis Reproduction Test
  • OECD 218 and 219 : Sediment-Water Chironomid Toxicity Using Spiked Sediment
  • OECD 211 : Daphnia magna Reproduction Test
  • OECD 222 : Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)
  • OECD 220 : Enchytraeid Reproduction Test
  • OECD 225 : Sediment-Water Lumbriculus Toxicity Test Using Spiked Sediment
  • OECD 226 : Predatory mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil
  • OECD 232 : Collembolan Reproduction Test in Soil
  • US EPA TG OPPTS 850.1500 : Fish lifecycle toxicity test
  • OECD 240 : Medaka Extended One Generation Reproduction Test (MEOGRT)
  • OECD 233 : Sediment-Water Chironomid Life-Cycle Toxicity Test (OECD TG 233)

Analytical method development and validation.

RRCo offers to develop and validate analytical methods allowing to track the test item when endocrine disruptors identifying.

 

RRCo offers assistance for the Endocrine Disruptors impact assessment.