Biocides

Rovaltain Research Company

Biocidal Product Regulation (BPR)

EU regulation on biocidal product n° 528/2012 (BPR), regulates their marketing authorisation and their use.

As part of this regulation, RRCo offers to determinate the physico-chemical parameters of the active substance (AS), to develop and validate analytical method to follow the substances and to determine the ecotoxicity of the active substance and the final product.

Physico-chemical parameters of the AS.

  • Purity of the active substance determination
  • Identity of impurities determination
  • 5 batche analysis – profile determination
  • Melting point (OECD 102)
  • pH determination
  • Boiling point (OECD 103)
  • Relative density (OECD 109)
  • Water solubility (OECD 105)
  • Partition coefficient (n-octanol/water) (OECD 107)
  • Hydrolysis as a function of pH (OECD 111)

Method development and validation

RRCo works in accordance with GLP quality system (area 8) and thus validate method in compliance with international norms and/or guidelines.
  • SANTE/11813/2017 Method validation for pesticide residues and analyse in the food and feed.
  • SANCO/3030/99 rev. 4 Technical Material and Preparations: Guidance for generating and reporting methods of analysis in support of pre- and post-registration data requirements for Annex II (part A, Section 4) and Annex III (part A, Section 5) of Directive 91/414.
  • SANCO/3029/99 Residues: Guidance for generating and reporting methods of analysis in support of pre-registration data requirements for Annex II (part A, Section 4) and Annex III (part A, Section 5) of Directive 91/414.
  • SANCO/825/00 rev 8.1 Pesticide residue analytical methods
  • NF T90-210 Mai 2009 Initial performances assessment protocol of laboratory method (French Norm)
  • Internal RRCo methods

RRCo, Expands Your horizons

Ecotoxicological studies

Toxicity on aquatic organisms
As part of BPR regulation, RRCo offers the tests listed here below in compliance with GLP statement.

        • Short term toxicity on fish (OECD 203)

       

    • Short term toxicity on aquatic invertebrates : Daphnia magna & others species (OECD 202)
    • Freshwater Alga and Cyanobacteria, Growth Inhibition Test (OECD 201)
    • Bioconcentration
      • Estimation method : n-octanol/water partition coefficient (OECD 107 or 117)
      • Dynamic test on fish (OECD 305)
    • Long term toxicity on fish
      • Fish, early-life stage toxicity test (OECD 210)
      • Fish, Short-term toxicity test on embryo and sac-fry stages (OECD 212)
      • Fish, juvenile growth test (OECD 215)
    • Long term toxicity tests on invertebrate
      • Daphnia magna and other species, reproduction test (OECD 211)
      • Toxicity tests on Chironomus sp. (OECD 218 & OECD 219)
    • Effects on aquatic macrophytes (OECD 238 & OECD 239)

 

Feel free to contact us via our online form.

Environmental Fate
  • Ready biodegradability (OECD 301 & OECD 310)
  • Inherent biodegradability (OECD 302)
  • Inherent biodegradability in the soil (OECD 304)
  • Biodegradability in sea water (OECD 306)
  • Aerobic and anaerobic transformation in soil (OECD 307)
  • Aerobic and anaerobic transformation in aquatic sediment systems (OECD 308)
  • Anaerobic Biodegradability of Organic Compounds in Digested Sludge: by Measurement of Gas Production (OECD 311)
  • Lixiviation sur colonne de sol (OCDE 312)
  • Simulation Tests to Assess the Biodegradability of Chemicals Discharged in Wastewater (OECD 314)
  • Hydrolysis as a function of pH (OECD 111)

Other tests on demand…

Terrestrial ecotoxicological tests

RRCo aims to offer tests allowing to define the ecotoxicity on terrestrial organisms and plants.

  • OECD 207 Earthworm, Acute Toxicity Tests
  • OECD 208 Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test
  • OECD 209 Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation)
  • OECD 216 Soil Microorganisms: Nitrogen Transformation Test
  • OECD 217 Soil Microorganisms: Carbon Transformation Test
  • OECD 222 Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)
  • OECD 227 Terrestrial Plant Test: Vegetative Vigour Test
  • OECD 232 Collembolan Reproduction Test in Soil
  • Aphidius rhopalosiphi : Mead Briggs et al. 2000 – A laboratory test for evaluating the effects of plant protection products on the parasitic wasp, Aphidius rhopalosiphi (DeStephani-Perez) (Hymenoptera, Braconidae)*
  • Aleochara : Grimm et al. 2000 – A test for evaluating the chronic effects of plant protection products on the rove beetle Aleochara bilineata Gyll. (Coleoptera : Staphylinidae) under laboratory*
  • Chrysoperla carnea : Vogt et al. 2000 – Laboratory method to test effects of plant protection products on larvae of Chrysoperla carnea (Neuroptera: Chrysopidae)*
  • OECD 226 : Preadory mites reproduction test in soil (Hypoaspis aculeifer)*
  • Pardosa sp.: Heimbach et al. 2000 – A method for testing effects of plant protection products on spiders of the genus Pardosa (Araneae, Lycosidae) under Laboratory conditions*
  • Total fauna : ACTA – Impact des produits phytosanitaires sur la faune auxiliaire, experimental methodology in orchards (1994)
  • Typhlodromus pyri : Blümel et al. 2000 – Laboratory residual contact test with the predatory mite Typhlodromus pyri Scheuten (Acari : Phytoseiidae) for regulatory testing of plant protection products
  • Typhlodromus pyri & Kampimodromus aberrans : *
    • Blümel et al. 2000 – Laboratory residual contact test with the predatory mite Typhlodromus pyri Scheuten (Acari : Phytoseiidae) for regulatory testing of plant protection products;
    • CEB N°192 : Méthode d’étude des effets non intentionnels sur les Phytoseiidae (=Typhlodromes) en arboriculture ;
    • CEB N°167 : Méthode pour l’évaluation des effets non intentionnels a moyen terme sur les phytoseiidae (=Typhlodromes) de la vigne des préparations PHYTOPHARMACEUTIQUES utilisées en traitement des parties aériennes

All our studies can be conducted in compliance with « Good Laboratory Practice »

RRCo aims to offer terrestrial ecotoxicological tests according to the OECD Guidelines or ISO norms.

For organic substance, RRCo offers to develop and validate analytical methods allowing test item monitoring during the various phase of test.
* Tests in partnership with ENIGMA

We can test the different species listed here below:

Adalia bipunctata, Amblydromalus limonicus, Amblyseius andersoni, Amblyseius californicus, Amblyseius cucumeris, Amblyseius degenerans, Amblyseius swirskii, Anagyrus fusciventris, Anagyrus pseudococci, Aphdius ervi, Aphelinus abdominalis, Aphidius colemani, Aphidius matricariae, Aphidoletes aphidimyza, Aphytis melinus, Atheta coriaria, Chilocurus nigritus, Coccinella septempunctata, Coccophagus sp., Cryptolaemus montrouzieri, Dacnusa sibirica, Delphastus catalinae, Diglyphus isaea, Encarsia citrina, Encarsia forsoma, Eretmocerus eremicus, Exochomus quadripustulatus, Feltiella acarisuga, Forficula auricularia, Leptomastidea abnormis, Leptomastix dactylopii, Leptomastix epona, Macrolophus, pygmaeus, Metaphycus flavus, Metaphycus helvolus, Microterys flavus, Neoseiulus californicus, Orius laevigatus, Phytoseiulus persimilis, Rodolia cardinalis, Sphaerophoria rueppellii

Stability-Storage

Stability and storage accelerated and long term tests

In the context of the biocide product regulation, RRCo offers in compliance with GLP stability and storage accelerated and long term tests

  • Analytical support : active substance dosing
  • Analytical support : impurity dosing,
  • Determination of pH values CIPAC MT 75
  • Dilution Stability of aqueous solution CIPAC MT 41,
  • Persistent foaming CIPAC MT 47,
  • Free acidity or alkalinity : CIPAC MT 31
  • Product and packaging appearance

Stability - Storage

Do you need stability/storage study? RRCo offers assistance in analytical method development and analysis of your product – accelerated and long term studies.

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